Johnson & Johnson Consumer Health Advances Field of Skincare for Cancer Patients

During oncology therapy, sufferers’ pores and skin requires particular care. Products reminiscent of Aveeno® Restorative Skin Therapy can assist sufferers of all pores and skin sorts keep away from extreme
cutaneous hostile reactions, to allow them to concentrate on life-saving therapies.

When Johnson & Johnson Consumer Health set out its Healthy Lives
Mission final
12 months, the corporate dedicated to addressing complicated, preventable well being points —
particularly, eradicating smoking and preventable pores and skin cancers — by collaborating on
initiatives each inside and out of doors the corporate.
One space the corporate has been investigating is the necessity for tailor-made skincare
for individuals with extremely sensitized pores and skin — together with most cancers sufferers. Taking
benefit of the power to companion with oncology consultants at its pharmaceutical
division, Janssen Pharmaceuticals, Inc., a staff pioneered analysis to review
the pores and skin harm which will happen in people who find themselves present process systemic most cancers
remedies.
Personal {and professional} connections
The examine resulted from a dialog at a 2017 drug supply convention.
Georgios Stamatas, PhD — a analysis affiliate director and fellow on the
Johnson & Johnson Consumer Health staff — acknowledged the identify of a speaker,
Mario Monshouwer, PhD from Janssen Research & Development, and linked
with him. The two bonded over shared experiences of relations impacted by
most cancers and mentioned its dramatic impression on high quality of life.
From their private {and professional} experiences, it was clear that — whereas the
final aim when treating most cancers is to save lots of lives, sure remedies can
have an effect on surrounding tissue and create pores and skin, intestine and urinary issues. In some
instances, the looks of pores and skin rashes throughout therapy really correlates with
increased affected person survival charges.
First-of-its-kind examine
The result’s a first-of-its-kind scientific examine printed in BMC Cancer,
which uncovered how sure oncology therapies negatively have an effect on the pores and skin
barrier. Skin-related unwanted side effects are frequent: 45 to one hundred pc of most cancers
sufferers expertise signs of impaired pores and skin barrier operate — together with pores and skin
irritation, an infection and dryness. Importantly, this new examine discovered that
sure courses of oncology medication can have a direct impact on the formation of
the pores and skin barrier; an irregular pores and skin barrier may be the explanation for the noticed
cutaneous hostile reactions.
During oncology remedy, sufferers’ pores and skin requires particular care to protect its
correct barrier operate and reduce hostile reactions. Scientists used a number of
distinctive strategies to display the results of oncology remedy on the pores and skin
barrier. By understanding the interconnection between the kinase inhibitor
therapies utilized in oncology
therapy and pores and skin well being, it turns into doable to check methods to assist
pores and skin well being throughout and after remedies, so sufferers can concentrate on life-saving
therapies. In additional analysis utilizing
phosphoproteomic and
transcriptomic analyses,
the staff found the precise molecular pathways in pores and skin cells which might be
affected by sure kinase inhibitors. These pathways are involving processes
linked to pores and skin barrier formation, irritation and oxidative stress. The outcomes
of these investigations had been printed this month in JID Innovations.
The rising subject of skincare for most cancers sufferers
The staff performed analysis to grasp which components and merchandise might
probably be used prophylactically to assist scale back unwanted side effects and therapy
interruption. These outcomes influenced one other examine from Johnson & Johnson
Consumer Health on the impression of the Aveeno® Restorative Skin Therapy
routine for sufferers present process systemic oncology remedies, which had been
lately introduced on the annual assembly of the American Academy of
Dermatology.
The examine discovered that Aveeno Restorative Skin Therapy supplies “important”
enchancment of high quality of life for most cancers sufferers’ pores and skin and itch reduction.
“Cancer sufferers present process therapy steadily report unfavourable, skin-related
unwanted side effects reminiscent of xerosis and pruritus — or dry pores and skin and itch; but, there are
few research evaluating potential cures,” Stamatas stated. “Our deep data
of the therapeutic advantages of oat led us to consider the Aveeno day by day skincare
routine can assist replenish the pores and skin barrier in most cancers sufferers who expertise
xerosis and pruritus on account of systemic oncological therapy.”
Aveeno® Restorative Skin Therapy
Aveeno Restorative Skin
Therapy was developed with
most cancers sufferers’ distinctive skincare wants in thoughts. The product routine was
clinically examined in partnership with main oncodermatologist, Dr. Mario
Lacouture, PhD. The mild formulations are free of fragrances, parabens,
sulphates and dyes; and 91 p.c of examine individuals reported an enchancment
in dry pores and skin inside three weeks of utilizing the Aveeno Restorative Skin Therapy
routine.
The routine consists of three merchandise: Oat Repairing Cream, Sulphate-Free
Body Wash and Itch Relief Balm. The merchandise harness properties of
naturally derived components reminiscent of oat — a strong antioxidant recognized to
moisturize and soothe dry pores and skin, aloe — which is thought to assuage pores and skin, and
Pro-Vitamin B5 — which helps to heal dry pores and skin.
Social mission
These research mirror Johnson & Johnson’s distinctive place as one of a number of
shopper firms with the power to conduct analysis with its personal
pharmaceutical or medical system colleagues.
“Through this work, we hope to enhance the standard of life of sufferers throughout
remedy by figuring out methods to keep away from extreme cutaneous hostile drug reactions
that may alter and even halt beneficial therapy remedy, so sufferers can focus
on life-saving therapies,” stated Caroline Tillett, Global Head of R&D at
Johnson & Johnson Consumer Health.
The firm stays dedicated to advancing the understanding of the impression of
most cancers therapies on pores and skin well being and delicate pores and skin; and creating sensible
options to assist individuals of all pores and skin sorts defend their pores and skin, proceed their
remedy and reside wholesome lives.

Published Jun 9, 2021 8am EDT / 5am PDT / 1pm BST / 2pm CEST

Sponsored Content
/ This article is sponsored by
Johnson & Johnson Consumer Health.
This article, produced in cooperation with the Sustainable Brands editorial staff, has been paid for by one of our sponsors.

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About the Author: Jessica