SKILLMAN, N.J., April 23, 2021 /PRNewswire/ — Johnson & Johnson Consumer Health as we speak introduced findings from one of the first medical research analyzing a every day skincare routine as adjunctive remedy for most cancers sufferers at the American Academy of Dermatology (AAD) Virtual Meeting Experience (VMX) 2021. The examine exhibits a every day Avena Sativa (Oat) skincare routine supplied a big enchancment in xerosis and pruritus (dry pores and skin and itch) for grownup sufferers present process systemic oncology remedies, indicating Aveeno Restorative Skin Therapy is secure and efficient for the administration of mild-to-moderate itch and/or dry pores and skin associated to systemic oncology remedies in adults.
“The final objective of most cancers remedy is to avoid wasting lives, which frequently includes taking an aggressive strategy to remedy which will result in unintended effects, together with degradation of the pores and skin barrier,” mentioned Caroline Tillett, Global Head R&D, Johnson & Johnson Consumer Health. “Johnson & Johnson Consumer Health is dedicated to offering therapeutic choices to help the entire affected person’s wants with secure and efficient over-the-counter options. We are happy to current the outcomes from amongst the first medical research analyzing a every day over-the-counter skincare routine displaying vital enchancment for most cancers sufferers’ pores and skin.”
Patients enrolled in the examine reported frequent unintended effects of mild-to-moderate xerosis (µ=1.5) and pruritus (µ=0.9) associated to their most cancers remedy. Patients used an Avena Sativa Skincare Regimen for 5 weeks, which included:
Aveeno’s Restorative Skin Therapy Sulfate-Free Body Wash used once-a-day for all showering. The physique wash incorporates antioxidant oat, aloe, and pro-vitamin B5.
Aveeno’s Restorative Skin Therapy Oat Repairing Cream utilized twice every day. The physique cream incorporates prebiotic oat focus, aloe, and pro-vitamin B5. It is formulated with out parabens, perfume, phthalates, and steroids.
Aveeno’s Restorative Skin Therapy Itch Relief Balm utilized as wanted. The anti-itch balm is formulated with prebiotic oat focus, aloe, pro-vitamin B5, and pramoxine HCl. The focused remedy is formulated with out parabens, perfume, phthalates, and steroids.
After 5 weeks, vital enhancements (p<0.05) in xerosis (µ=0.5) and pruritus (µ=0.4) had been noticed in accordance with dermatologist reported Common Terminology Criteria Adverse Events (CTCAE) scoring and Patient Reported Outcomes Common Terminology Criteria Adverse Events (PROCTCAE) scoring. The routine was nicely tolerated and no critical product-related opposed occasions had been noticed. Patients additionally reported vital enhancements (p<0.05) in pores and skin moisture with the routine. They perceived vital enhancements of their Quality of Life as measured by Skindex-16 scores together with their signs, emotional, and practical affect. The Role of the Skin Barrier in Cancer Treatment Side Effects Cancer remedy with kinase inhibitors typically leads to skin-related unintended effects, also referred to as Cutaneous Adverse Drug Reactions (CADRs), which may considerably affect sufferers' high quality of life. Examples of CADRs are pores and skin irritation, infections, itch, and different signs, and are frequent following administration of Epidermal Growth Factor Receptor inhibitors (EGFRis). In a Johnson & Johnson Consumer Health and Janssen Pharmaceutical Companies of Johnson & Johnson evaluation analyzing the results of eight EGFRis and Vascular Endothelial Growth Factor Receptor inhibitors (VEGFRis) (3, 10, 30, 100nM) on human keratinocytes in a novel 3D micro-skin tissue tradition mannequin, outcomes demonstrated that most cancers remedy can instantly affect cell development and differentiation on the floor of the pores and skin. "The pores and skin barrier is significantly impacted by sure most cancers remedies. As the pores and skin cells regular programming is altered, the pores and skin barrier is broken, permitting water to flee extra simply and irritants to extra simply penetrate the pores and skin," mentioned Dr. Georgios Stamatas, Research Associate Director and Fellow, Johnson & Johnson Consumer Health. "Johnson & Johnson Consumer Health and Janssen Pharmaceutical Companies of Johnson & Johnson have proven with this newest analysis that we will considerably enhance mild-to-moderate skin-related unintended effects with topical options, serving to sufferers focus on their most cancers remedy." In a full thickness reconstructed human dermis (RHE) mannequin a lower in trans-epidermal water loss (TEWL) price was noticed, indicating the pores and skin barrier was compromised. The examine confirmed that topical remedy of the RHE with emollient formulations throughout EGFRi remedy can scale back, and even fully inhibit, the TEWL enhance ensuing from remedy with EGFRis. The examine confirmed that topical emollients will help enhance pores and skin barrier harm and subsequent pores and skin irritations. Access to all Johnson & Johnson Consumer Health accepted research and creator movies might be out there by way of the AAD VMX portal for AAD registrants. About the Consumer Health enterprise of Johnson & Johnson At Johnson & Johnson Consumer Health, we're pushed to enhance the private well being of folks in all places. Our differentiated portfolio of iconic manufacturers, together with Tylenol®, Zarbee's®, Neutrogena®, Aveeno®, Listerine®, OGX®, and Johnson's®, delivers life-enhancing, first-to-market innovation. By combining the energy of science with significant human insights and digital-first pondering, we assist greater than 1.2 billion folks dwell more healthy lives on daily basis, from their very first day. SOURCE Johnson & Johnson
